We evaluated neutralization titers of 62 IVIGs and 15 CPs, including pre-pandemic 2019-IVIG (n = 20), 2020-IVIG (n = 8), 2020 convalescent plasma (2020-CP; n = 7), 2022 convalescent plasma (2022-CP; n = 8), post-infection hyperimmunoglobulin IVIG (pi-hCoV-2IG; n = 17), 2023-IVIG (n = 9), 2024-IVIG (n = 7), and 1 post-vaccination hyperimmunoglobulin IVIG (Vx-hCoV-2IG) against the original WA-1 strain and 8 SARS-CoV-2 variants that circulated in 2024. This evidence concerns the gene CP and infection.