Gene Ontology (GO) enrichment analysis of the differentially expressed proteins indicated that the downregulated proteins in the Vpr peptide treatment group were mainly cytoskeletal proteins or proteins associated with cytoskeletal functions, suggesting that the Vpr peptide may inhibit tumor cell invasion and metastasis by disrupting the maintenance of tumor cell morphology and suppressing tumor cell motility (Figure 9B). This evidence concerns the gene DNM2 and neoplasm.