One possible explanation is that mRNA COVID-19 vaccines, while highly effective in generating antiviral immunity, might concurrently activate neoplastic T-cell clones via the stimulation of the nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and the signal transducer and activator of transcription 3 (STAT3) signaling pathways. Here, NFKB1 is linked to COVID-19.