For example, Moon et al. designed a high-density lipoprotein-mimicking nanodiscs delivery strategy that co-delivered neo-epitopes and the adjuvant CPG, significantly improved the delivery efficiency of antigen in vivo, improving delivery efficiency and enhancing the frequency of neoantigen-specific CD8α+ cytotoxic T lymphocytes (47 times higher), and effectively inhibiting the tumor growth of B16F10 and MC38 tumor-bearing mice [300]. The gene discussed is CD8A; the disease is neoplasm.