Studies have demonstrated that SARS-CoV-2 can directly infect human microglial cells, leading to their activation and triggering a pro-inflammatory response, including the release of IL-1β, IL-6, and TNF-α, which are associated with neuroinflammation and may underlie the neurological symptoms observed in COVID-19 [30], which closely resembles the pathogenic mechanisms seen in HIV associated neurocognitive disorders [53]. This evidence concerns the gene TNF and COVID-19.