As a matter of fact, relevant experiments indicate that fractalkine can enhance the anti-tumor effect of the immune system against HCC in mice: Tang et al. observed that CX3CL1 can elicit tumor-specific cytotoxic T cells and an increased production of IL-2 and IFN-γ capable of inhibiting tumor growth [28]. Here, CX3CL1 is linked to hepatocellular carcinoma.