Notably, PBLs in the GCRV group have also shown an obvious antiviral response characterized by the upregulation of interferon-related genes (e.g., IFNγ, IFNα, and IFNβ) (Figure S1B,C), suggesting that viral infection could also activate nucleic acid-mediated cellular defenses through antiviral signaling pathways including TLR-like receptor, JAK-STAT, and cGAS-STING (Figure S1D). Here, IFNB1 is linked to viral infectious disease.