Specifically, Kang et al. have reported the pull-down of IFI16 during IP of MTA-1, a critical scaffolding component of the NuRD complex, proposing that the MTA1-IFI16 complex may play a significant role in the epigenetic regulation of estrogen receptor alpha (ERα) expression in breast cancer [72]. This evidence concerns the gene ESR1 and breast carcinoma.