In the case of JEV infection, it has been shown that entry is independent of clathrin, while the regulatory proteins of actin filaments, such as RHOA, RAC1, proteins of the ARP2/3 complex, and the N-WASP family (LIMK1, PAK1, and ROCK2), are crucial for the establishment of infection [104]. The gene discussed is RAC1; the disease is infection.