After adjustment for years on ART, HCV genotype, current ART type, TAF use, current HIV-RNA, CD4 count, diabetes, BMI, and age, a significant reduction in CAP changes over time (β = −2.85, 95% CI: −5.07 to −0.64, p = 0.01) was associated with the presence of dyslipidemia. The gene discussed is CD4; the disease is metabolic syndrome.