Recent data has indicated that certain drugs used for the treatment of COVID-19 patients, such as azithromycin, chloroquine diphosphate, hydroxychloroquine sulfate, and nafamostat mesylate [24,25], increased viral lytic gene expression via the activation of MAPK and NF-kB signalling pathways [26]. The gene discussed is NFKB1; the disease is COVID-19.