NECTIN1 and infection: Therefore, the extracts may directly bind to viral glycoprotein gB, gC, gH, gK, gL, or gL, particularly gD, which binds to the major receptors including herpesvirus entry mediator, Nectin1, Nectin2, and 3-O-sulfated heparan sulfate proteoglycan, resulting in the inhibition of viral attachment and infection [32].