DDIT3 and non-small cell lung carcinoma: Zhang et al. [84] have shown that MeJA induces apoptosis in human non-small cell lung cancer cells via the DDIT3–TNFRSF10B–caspase axis, where the stress-induced transcription factor DDIT3 upregulates the death receptor (TNFRSF10B), leading to caspase activation.