CDK5RAP1 also binds cyclin-dependent protein kinase 5 (CDK5) and prevents its activation by impeding CDK5/p53 complex formation; the loss of CDK5RAP1 leads to CDK5 hyperactivity and has been linked to neurodegenerative disorders, including Alzheimer’s disease [58]. Here, CDK5RAP1 is linked to early-onset autosomal dominant Alzheimer disease.