Clinical trials report improvements in anthropometric variables and metabolic indicators such as fasting glucose, HbA1c, HOMA-IR, TC, TG, and LDL-C, as well as in inflammatory markers including hs-CRP and IL-6, validating the potential clinical applicability of ginger as a therapeutic complement in the treatment of obesity and pathologies that share immunometabolic dysfunctions. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.