In Wistar male rats with HFD-induced obesity, 30-day supplementation with 6-gingerol led to lower body weight, reduced adipose tissue, and decreased levels of leptin, glucose, insulin, and serum lipid profiles compared to the control group, particularly at the dose of 75 mg/kg/day [47]. This evidence concerns the gene LEP and obesity due to melanocortin 4 receptor deficiency.