In RAW 264.7 macrophage cultures stimulated with lipopolysaccharide (LPS), 6-gingerol administration markedly attenuated reactive oxygen species (ROS) production and inducible nitric oxide synthase (iNOS) expression, indicating interference with canonical inflammatory pathways implicated in obesity pathogenesis [40,41]. Here, NOS2 is linked to obesity due to melanocortin 4 receptor deficiency.