In the process of periodontitis, chemokines such as CXCL-8, CXCL-1, and CCL-5 and cytokines such as TNF-α, IL-1β, and IL-6 are present, due to the action of these multi-factors, it progresses to severe periodontitis with loss of periodontal support structures [32,33]. This evidence concerns the gene CCL5 and periodontitis.