TNF and colorectal neoplasm: In vivo experiments showed that KGM-CUR/PSM microspheres effectively inhibited the growth of colorectal tumors, down-regulated the expression of TNF-α, IL-1β, and IL-6 in serum and tissues, inhibited the production of MPO enzyme and pro-inflammatory bacteria, reduced the damage to the intestine, adjusted the ratio among microbiota, and restored the richness and diversity of intestinal microbiota in vivo.