In vivo experiments showed that KGM-CUR/PSM microspheres effectively inhibited the growth of colorectal tumors, down-regulated the expression of TNF-α, IL-1β, and IL-6 in serum and tissues, inhibited the production of MPO enzyme and pro-inflammatory bacteria, reduced the damage to the intestine, adjusted the ratio among microbiota, and restored the richness and diversity of intestinal microbiota in vivo. This evidence concerns the gene IL1B and colorectal neoplasm.