TNF and cancer: Owing to the effect of ROS-sensitive bonds, the expression levels of inflammation factors in the CUR/PSM micelles group were lower than those of the CUR/PM micelles group, and the KGM-CUR/PSM microspheres group with a dual-response release mechanism showed the most significant effect on reducing the expression of TNF-α, IL-1β, and IL-6, which could block the inflammatory-cancer transformation through the anti-inflammatory effect, thus enhancing the anti-tumor effect.