SHH and familial pancreatic carcinoma: While stroma elimination was envisioned as revolutionizing the treatment of pancreatic cancer, some clinical trials targeting stroma have brought disappointing results, such as the inhibition of profibrogenic pathways using the sonic hedgehog (SHH) pathway inhibitor [214,215,216] and the degradation of the extracellular matrix using PEGylated hyaluronidase (PEGPH20) [217,218].