Similarly, β-glucans from G. lucidum (50–200 μg/mL) were shown to upregulate the M1 phenotype markers (e.g., IL-12, IFN-γ) in tumor-associated macrophages but reduce the M2 phenotype markers (e.g., TGF-β, IL-10) in the TME [96]. Here, TGFB1 is linked to neoplasm.