USP7 and neoplasm: While USP7 inhibition has been shown to reverse the iTME in subcutaneous Lewis cancer models [134], its role in BM was specifically addressed by Lu et al. [135] They found that microparticles (MPs) released from radiation-treated tumor cells (RMPs) had a stronger capacity to activate macrophages in vitro than MPs derived from tumor cells treated with other stimuli, including chemotherapy, UV radiation, or normal culture [135].