Wu et al. developed hydroxyethyl starch-cholesterol self-assembled nanoparticles co-delivering fucoxanthin and Twist siRNA, demonstrating synergistic antitumor efficacy in triple-negative breast cancer (TNBC) through tumor cell proliferation/metastasis inhibition, apoptosis promotion, aberrant angiogenesis blockade, and cancer-associated fibroblast (CAF) activation/collagen deposition suppression in tumor microenvironments, while enhancing drug penetration into tumor stroma. The gene discussed is TWIST1; the disease is neoplasm.