(1) Promoted focal necrosis in tumor tissues.(2) Triggered tumor cell apoptosis in a dose-dependent way.(3) Caused anti-apoptotic factor (e.g., Bcl-2, CyclinD1, Ki-67) suppression and apoptotic (Bax) secretion, and inhibited tumor growth/metastasis. The gene discussed is MKI67; the disease is neoplasm.