Kim et al. reported that while SIRT1/AMPK and PPARα signaling pathways were downregulated in a mouse model of age-related renal injury, resveratrol improved renal function, reduced proteinuria, and lessened glomerulosclerosis by activating Nrf2 signaling and enhancing SIRT1/AMPK and PPARα pathways in the kidneys. The gene discussed is SIRT1; the disease is glomerulosclerosis.