IFNG and neoplasm: The TME significantly involves TAMs, which are derived from circulating monocytic precursors and are directed toward the tumor and are induced by interferon-gamma (IFN-γ)-mediated classical activation or alternatively by the helper T 2 cells (Th2) and cytokines like interleukin-4 (IL-4) and interleukin-13 (IL-13).