Conversely, the NF-κB pathway upregulates pro-inflammatory cytokines (interleukin-6 (IL-6), VEGF, (IL-8)), Inducible nitric oxide synthase (iNOs), TGF-β, indirectly boosts WNT/β-catenin, thus fueling inflammation and tumor growth. The gene discussed is NOS2; the disease is neoplasm.