Low-GI/GL diets or low carbohydrate intake did not affect either HOMA-IR, HDL cholesterol, waist circumference, diastolic pressure [172,173,176], nor inflammatory biomarkers such as C-reactive protein (CRP), tumor necrosis factor alpha, interleukin-6, or leptin, which can be involved in the development of insulin resistance and subsequently lead to T2D [177]. The gene discussed is CRP; the disease is Insulin resistance.