A higher dietary fiber intake was instead associated with a reduced incidence of T2D among carriers of the risk (T) allele in the rs10923931 variant of Neurogenic locus notch homolog protein 2 (NOTCH2) and among homozygotes for the risk (G) allele in Zinc-finger BED domain-containing 3 (ZBED3) rs445705 [144]. This evidence concerns the gene ZBED3 and type 2 diabetes mellitus.