In addition to being involved in the modulation of Wnt/beta-catenin signaling, increasing levels of ZBED3 are independently associated with insulin resistance and risk of T2D, and ZBED3 has recently been identified as a regulator of hepatic glucose metabolism, promoting hepatic gluconeogenesis under glucagon stimulation and thus regulating T2D progression [150,151,152]. This evidence concerns the gene ZBED3 and type 2 diabetes mellitus.