Amenorrheic women—thus, with hypoestrogenism—have greater increases in heart rate, blood pressure, and cortisol levels in response to psychological stress: low levels of gonadal hormones, oxytocin, and leptin and high levels of cortisol and PYY have been implicated in the psychopathology of eating disorders and the symptoms of anxiety and depression in AN [162]. Here, LEP is linked to eating disorder.