Furthermore, AlCl3/D-gal induced the downregulation of the brain expression of ZO-1 and claudin5 (p < 0.01 for both) compared with the normal group, while SCEP treatment reversed the downtrend in model mice (p < 0.05 for ZO-1, p < 0.05 for claudin5) (Figure 7G–J), indicating that SCEP alleviated BBB dysfunction in AD model mice. The gene discussed is TJP1; the disease is Alzheimer disease.