STAT3 and Parkinson disease: BHB, a ketone body increased during fasting, upregulates SIRT3 in midbrain neurons, inhibits pyroptosis by downregulating signal transducer and activator of transcription 3 (STAT3)-mediated NLRP3 inflammasome activation for PD models in vivo and in vitro, improving mitochondrial antioxidant defences, and reducing α-synuclein oligomerisation [94,95].