From a molecular point of view, the absence of E6/E7 means that HPV does not degrade the cellular genes TP53 and RB; therefore, mutations of TP53 and other tumor oncosuppressor genes (e.g., STK11, PTEN) and oncogenes (such as KRAS, PIK3CA, and ARID1A) are frequently detected in HPV-negative tumors [13]. Here, TP53 is linked to neoplasm.