EGFR and lung adenocarcinoma: In this study, we also found that ginsenoside Rg3 has an effect on down-regulating the copy number of EGFR in both EGFR-wild-type and mutant lung adenocarcinoma cells, but its effect is more pronounced in EGFR-mutant lung adenocarcinoma cells, which may be an important mechanism for its potentiating effect on EGFR-TKI-like agents against cancer.