Zebrafish are also used to model other primary lymphoedema subtypes including Milroy disease (fms-related receptor tyrosine kinase 4 (flt4, zebrafish orthologue of VEGFR3) mutant) [104], Milroy-like disease (vegfc mutant) [105,106], and Emberger syndrome (GATA-binding protein 2a (gata2a) mutant) [82,83]. The gene discussed is VEGFC; the disease is Milroy disease.