PIK3CA and malignant colon neoplasm: Molecular docking simulates ligand–target binding, with SystemsDock identifying swertisin/cryptotanshinone as key components in Naozhenning granules [59], Auto Dock Tools revealing coumarin-dithiocarbamate as the α-glucosidase inhibitor backbone [60], and Discovery Studio confirming ginger’s anti-colon cancer action via PI3K-Akt/EGFR pathways [61].