SELENBP1 and Insulin resistance: In this study, the levels of homocysteine, succinic acid, and Selenbp1 were detected to be significantly higher in the MOD group than in the CON group, and DNL significantly reduced the levels of cysteine, succinic acid, and Selenbp1, exerting anti-inflammatory, anti-insulin resistance, and alleviating T2DM symptoms.