FGF2 and neoplasm: These are activated by signals released by tumor cells, such as transforming growth factor beta (TGFβ), fibroblast growth factor 2 (FGF2), and platelet derived growth factor (PDGF), and play a very important role because they secrete both growth factors, which not only support the growth and survival of malignant cells, but also act as chemotactic factors, and metalloproteases (MMPs) that allow the remodeling of the matrix [14].