FOXP3 and neoplasm: Consequently, inhibiting Grp94 can selectively debilitate Tregs: genetic ablation of Grp94 in Foxp3+ Tregs was shown to abolish Treg accumulation in the tumor microenvironment and to destabilize the Treg lineage, evidenced by reduced Foxp3 expression and conversion of some Tregs into interferon-γ–producing ex-Tregs [161,165].