PRRT2 and rheumatoid arthritis: Finally, to conduct a more in-depth exploration of the mechanism, we hypothesize that IOP regulates calcium ions, which in turn regulates PKC (protein kinase C)/CaMKII (Calcium–calmodulin (CaM)-dependent protein kinase II), inhibits IKK, thereby inhibiting the translocation of p65 to the nucleus, and thereby inhibiting the assembly of the NLRP3 inflammasome, and ultimately suppressing the inflammation of RA.