In addition, our previous study found that IOP mitigated the inflammatory symptoms of dextran sulfate sodium (DSS)-induced colitis in mice by regulating the JAK-STAT signaling pathway and suppressing the levels of pro-inflammatory cytokines in activated T cells to balance T helper cell 1 (Th1)/Th2 and Th17/Treg functions [21]. This evidence concerns the gene SOAT1 and colitis.