HMOX1 and Cognitive impairment: Conversely, emerging evidence indicates that LCZ696 may exert neuroprotective effects in drug-induced cognitive deficits: a recent study demonstrated that LCZ696 significantly improved METH-induced cognitive impairment in mice by activating the Nrf2/HO-1 pathway, reducing apoptosis and oxidative stress in the VTA and SH-SY5Y cells [20].