NFKB1 and colorectal cancer: The apoptosis induction by bardoxolone methyl was accompanied by the suppression of pro-survival signaling proteins, including Akt, NF-κB, and mTOR, as well as NF-κB-regulated anti-apoptotic proteins such as Bcl-2, Bcl-xL, Bad, and survivin, suggesting that bardoxolone methyl displays a good potential for therapeutical treatment for advanced, chemotherapy-refractory colorectal cancer [100].