BRCA1 and neoplasm: Moreover, it was observed that the levels of ErbB2, phosphorylated ErbB2 (p-ErbB2), and cyclin D1 progressively increased over time in the mammary glands of BRCA1-deficient mice and the treatment with bardoxolone methyl inhibited the persistent phosphorylation of ErbB2 in the tumor tissues of these mice.