AKT1 and neoplasm: The primary mechanism of tumor cell destruction was apoptosis which was accompanied by the activation of caspases-3, -8, and -9, mitochondrial depolarization, the release of cytochrome c from mitochondria and downregulation of the anti-apoptotic proteins p-AKT, NF-κB, and Notch1, highlighting the potential of bardoxolone methyl for the treatment of aggressive brain tumors [107].