Moreover, NAC pretreatment reversed the downregulation of the anti-apoptotic proteins p-AKT, p-mTOR, NF-κB, BCL-2, BCL-xL, c-IAP1 and survivin, suggesting that ROS play a key role in mediating the antiproliferative and apoptosis-inducing effects of bardoxolone methyl in ovarian cancer cells [104]. This evidence concerns the gene AKT1 and ovarian carcinoma.