Integrin αvβ3 binds various ECM proteins, such as fibronectin, vitronectin, von Willebrand factor, fibrinogen, osteopontin, and thrombospondin, through their RGD motif, but also Vascular Endothelial Growth Factor (VEGF) receptors, Fibroblast Growth Factor-1 and 2 (FGF-1 and 2), and Insulin Growth Factor 1 (IGF-1), promoting cancer cell invasiveness [14]. The gene discussed is SPP1; the disease is cancer.