Additionally, the cGAS/STING pathway also promotes the phosphorylation of the downstream protein IRF3 [46,47], and these transcription factors, once in the nucleus, further enhance the transcription of inflammatory factors such as TNF-α, IL-6, and IL-1β [48], worsening kidney damage in DN and ultimately leading to renal failure. This evidence concerns the gene IRF3 and Nephropathy.