AKT1 and Stroke: For example, previous research pointed out that AKT1 does not affect stroke and augmentation of this pathway may not be a feasible approach to neuroprotection in stroke [19]; later research then came out with opposite ideas: the role of AKT1 in stroke neuroprotection is important, and active compounds such as H2S/Atorvastatin can attenuate the damage through pathways related to AKT1 [20,21].