CD8A and colorectal carcinoma: Interestingly, the association of specific leukocyte subtype densities in CRC with tissue Fn content has identified negative association with overall T lymphocyte (CD3+) density and memory-type helper T cell density (CD3+CD4+CD45RO+), whereas CD8+ lymphocyte density and M1-like and M2-like macrophage densities were not associated with Fn content [23].