After adjusting for BMI, fasting glucose levels, DM, smoking, and CRP levels, every 1 pmol/L increase in the serum sclerostin level was related to a 5.4% increase in the odds of having PAD, on average (OR: 1.054, 95% confidence interval [CI]: 1.019–1.090; p = 0.002). Here, CRP is linked to peripheral arterial disease.