KCNQ1OT1 and Beckwith-Wiedemann syndrome: For example, abnormal methylation patterns of KvDMR1 have been observed in humans with Beckwith-Wiedemann Syndrome (BWS) following ART procedures, and hypomethylation of this locus has been found in bovine conceptuses derived from ART, which showed signs of Large Offspring Syndrome (LOS) [157,158,159,160,161,162].