In our study, a likely pathogenic variant, NM_001199397.3(NEK1):c.3191C>G (p.Ser1064Ter), was identified TGM6 (NM_198994.3) in a 66-year-old male patient with a 20-year history of ET that has been followed for PD development over the last 5 years (Patient No. 3 in Table 1 and Table 2). The gene discussed is NEK1; the disease is Parkinson disease.