In psoriasis, various stress-related triggers—ranging from environmental factors to genetic predispositions—can activate innate immune cells and keratinocytes to produce tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ), IFN-α, interleukin-6 (IL-6), and interleukin-1β (IL-1β) [35]. The gene discussed is TNF; the disease is psoriasis.