IL18 and psoriasis: In the study conducted by Ozer Arican et al. [68], the findings corroborated previously published data, indicating that Th1-associated cytokines (TNF-α, IFN-γ, and IL-12), along with several pro-inflammatory cytokines (including IL-6, IL-8, and IL-18), exhibit altered serum levels in patients with psoriasis.