Unlike the impact of A20 and Cezanne, the CYLD p.E747K and c.2242+169 variants in the exon 15 had protective effects for B-ALL in this study, although CYLD inactivation is related to the pathogenesis of T-lymphoblastic leukemia and cancers [14,15]. Here, TNFAIP3 is linked to acute lymphoblastic leukemia.