TP53 and endometrial cancer: Currently, The Cancer Genome Atlas (TCGA) has classified four novel molecular endometrial cancer subgroups: (I) POLE/ultramutated (POLE-mutated); (II) microsatellite-instability/hypermutated (MSI-H)/mismatch-repair-deficient (dMMR); (III) copy number-high/TP53-abnormal(p53-abn); and (IV) copy-number-low/TP53-wild-type, which also refers to no specific molecular profile (NSMP) endometrial cancers [5,80,81,82].