Some biomarkers that indicate sepsis-related endothelium injury and coagulation dysfunction have been used, such as thrombomodulin (sTM), thrombin–antithrombin complex (TAT), tissue plasminogen activator–inhibitor complex (t-PAIC) and α2-plasmin inhibitor–plasmin complex (PIC) [30]. This evidence concerns the gene THBD and Sepsis.