NETs cascade end-products, including neutrophil elastase (NE), circulating free DNA (cfDNA, citrullinated histone 3 (citH3) and myeloperoxidase (MPO), not only play a crucial role in sepsis-related immune-regulated immunothrombosis and sepsis complications but could also serve as efficient biomarkers to predict unfavorable outcomes, such as mortality and ARDS development. This evidence concerns the gene ELANE and Sepsis.