Their increase offers an additional diagnostic value to CRP for sepsis diagnosis as CRP, cfDNA and MPO-DNA AUCs were 0.777 (95% CI: 0.680–0.873), 0.744 (95% CI: 0.650–0.838) and 0.719 (95% CI: 0.628–0.809), respectively, while the combination of them outperformed all biomarkers alone and all dual combinations as well with an AUC of 0.865 (95% CI: 0.795–0.919). Here, CRP is linked to Sepsis.