NETs cascade end-products, including neutrophil elastase (NE), circulating free DNA (cfDNA, citrullinated histone 3 (citH3) and myeloperoxidase (MPO), not only play a crucial role in sepsis-related immune-regulated immunothrombosis and sepsis complications but could also serve as efficient biomarkers to predict unfavorable outcomes, such as mortality and ARDS development. This evidence concerns the gene MPO and acute respiratory distress syndrome.