HNF1A and liver cancer: Previous ChIP-sequencing from the ENCODE project in HepG2 cells, a liver cancer cell line that expresses HNF1A, and from our group in UM5 cells found an HNF1A binding peak, which contains the HNF1A binding sequence, in the FGFR4 enhancer region found in the first intron of the FGFR4 locus (Supp Fig. 3B) [6, 11, 41].