AD neuropathology is primarily characterized by the accumulation of amyloid beta (Aβ) plaques and intracellular neurofibrillary tangles (NFTs) composed of hyperphosphorylated tau protein,4 whereas T2D is marked by pancreatic amyloid plaques composed of the protein amylin, also known as islet amyloid polypeptide (IAPP).5, 6, 7, 8, 9. Here, MAPT is linked to type 2 diabetes mellitus.