The relative abundance of Saccharimonadales in the gut of mouse models of colon cancer was significantly greater than that in healthy controls, and the expression of Saccharimonadales and the phospholysine phosphistidine inorganic pyrophosphatase (LHPP) gene was negatively correlated with that of Saccharimonadales [11]. Here, LHPP is linked to colonic neoplasm.